Process Pharma Technologies

The Critical Role of Human Blood in Modern Medicine

Human blood is indispensable not only for transfusions but also for the development of life-saving therapies. Plasma-derived medicinal products—extracted from donated blood—are essential in treating a wide range of conditions, from hemophilia and immune deficiencies to viral pandemics. Plasma derived therapies are in high demand, and their production involves a series of highly specialized, tightly controlled processes. Precision across the entire value chain ensures that every drop of plasma is used to its fullest therapeutic potential.

A Growing Market with Rising Demands

The global demand for plasma derivatives continues to rise, driven by advancements in medical technology and an increasing prevalence of rare and chronic diseases. While recombinant techniques—those using genetic engineering—have reduced reliance on human plasma for some therapies, many vital proteins such as albumin, immunoglobulins, and coagulation factors are still best sourced from plasma. Concurrently, improvements in plasma fractionation technology have boosted the yield and purity of these valuable components.

At the same time, the growing incidence of blood clotting disorders, rare genetic diseases, and immune-related conditions further underscores the importance of a stable and scalable plasma supply. Meeting this demand requires not only raw materials, but also sophisticated, high-yield processes that minimize waste and ensure patient safety.

From Donation to Therapy: A Complex Journey

Before plasma can become a safe and effective medication, it must undergo multiple rigorous processing stages. Typically delivered frozen, donated plasma is first thawed, then fractionated, purified, formulated, and finally filled, freeze-dried, pasteurized, and inspected—depending on the final product requirements.

Given the complexity of these operations and the scarcity of human plasma, precision and process control are vital. Every milliliter lost during production not only impacts cost but also represents a missed opportunity to treat a patient in need. For this reason, manufacturers prioritize high recovery rates, process flexibility, and consistently high product quality.

Thawing and Fractionation: Precision at the Core

The journey begins with thawing frozen plasma, typically supplied in large bags or bottles sourced from multiple donors. To preserve the integrity of sensitive proteins, thawing must occur gradually in specialized systems designed to gently mix and warm the material under low shear conditions.

Once thawed, the plasma undergoes fractionation—where it is separated into components like albumin, immunoglobulins, fibrinogen, and other coagulation factors. This process relies on a series of precise filtration steps, which isolate proteins based on size, charge, and affinity. Such complex processing demands advanced, scalable equipment capable of delivering stable, efficient results at industrial volumes.

Integrated Systems for High-Quality Demand Expert Services

Process Pharma Technologies provides All-in-one, fully automated solutions from a single provider help ensure continuous monitoring, seamless integration, and control of critical process parameters. Each phase of the process of plasma fraction process requires rigorous measures to remove impurities and inactivate viruses using chemical or heat-based methods.​